Figure 3.

Time to sustained clinically meaningful deterioration (A) Kaplan–Meier plot for EORTC QLQ-C30 Global Health Status and (B) Forest plot for EORTC QLQ-C30 Global Health Status, physical functioning and symptom scales. Patients with baseline scores ≥10 were included in analyses of Global Health Status and physical functioning scores; patients with baseline scores ≤90 were included in analyses of symptom scores. Patients who had not had a TSCMD event or who had a TSCMD event after two or more missed HRQoL assessment visits were censored at the time of their last HRQoL assessment where the respective score could be evaluated; however, patients were not censored if they had two missing visits between two evaluable HRQoL assessments (and the outcome of the second assessment was not deterioration) and subsequently went on to show sustained clinically meaningful deterioration. CI, confidence interval.