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. 2019 Dec 31;12:1. doi: 10.1186/s13148-019-0796-9

Fig. 4.

Fig. 4

Age-related alterations in CpG − 628 methylation rate and pressure pain threshold. a In healthy participants, CpG − 628 methylation rate declines with increasing age. In contrast, it increases in Crohn patients. b PPT rises with increasing age in both cohorts