Table 4.
Toxicity profile for all patients
| Side effects | TKI-naïve (%) (N = 207) | TKI-resistant (N = 137) | ||
|---|---|---|---|---|
| All grades, N. (%) | Grade III/IV, N. (%) | All grades, N. (%) | Grade III/IV, N. (%) | |
| Fatigue | 117 (56.5) | 19 (9.1) | 81 (59.1) | 14 (10.2) |
| Anorexia | 84 (40.5) | 18 (8.7) | 56 (40.9) | 10 (7.3) |
| Diarrhea | 23 (11.1) | 4 (0.2) | 12 (8.8) | 1 (0.7) |
| Nausea | 142 (68.6) | 38 (18.4) | 95 (69.3) | 23 (16.8) |
| Vomiting | 134 (64.7) | 15 (7.2) | 83 (60.6) | 15 (10.9) |
| Headache | 105 (50.7) | 14 (6.8) | 51 (37.2) | 12 (8.8) |
| Anemia | 113 (54.6) | 5 (2.4) | 75 (54.1) | 3 (2.2) |
| Neutropenia | 95 (45.9) | 17 (8.2) | 69 (50.4) | 11 (8.0) |
| Thrombocytopenia | 88 (42.5) | 6 (2.9) | 62 (45.3) | 2 (1.5) |
Abbreviations: TKI tyrosine kinase inhibitors