Table 4.
The relationships between the concentrations of 25(OH) D and the genotypes of the VDR gene variants in mothers and their preterm and full-term newborns
| VDR SNVs | Genotypes | N | Preterm | N | Full-term | P ** | ||
|---|---|---|---|---|---|---|---|---|
| % | Vitamin D* (ng/mL) | % | Vitamin D* (ng/mL) | |||||
| Mothers (n = 132) | ||||||||
| TaqI/A > G | AA | 19 | 47.5 | 20.90 (16.18; 25.62) | 25 | 27.2 | 24.74 (20.025 28.09) | 0.291 |
| AG | 18 | 45.0 | 20.83 (13.79; 27.87) | 46 | 50.0 | 28.05 (25.010; 30.96) | 0.023 | |
| GG | 3 | 7.5 | 19.90 (−10.42; 50.22) | 21 | 22.8 | 25.24 (21.30; 29.17) | 0.348 | |
| BsmI/C > T | CC | 15 | 37.5 | 21.54 (16.17; 26.91) | 34 | 37.0 | 26.48 (22.77; 30.19) | 0.131 |
| CT | 0 | 0.0 | – | 35 | 38.0 | 28.24(24.75; 31.73) | *** | |
| TT | 25 | 62.5 | 20.35 (14.95; 25.75) | 23 | 25.0 | 23.93 (21.00; 26.87) | 0.245 | |
| ApaI/C > A | CC | 5 | 12.5 | 20.28 (14.26; 26.30) | 31 | 33.7 | 24.07 (20.71; 27.43) | 0.375 |
| CA | 21 | 52.5 | 23.71 (17.47; 29.96) | 49 | 53.3 | 28.04 (25.27 30. 80) | 0.136 | |
| AA | 14 | 35.0 | 16.60 (11.17; 22.04) | 12 | 13.0 | 26.60 (19.80; 33. 40) | 0.018 | |
| FokI/A > G | AA | 4 | 10.0 | 20.71 (−9.45; 50.88) | 16 | 17.4 | 26.61 (22.08; 31.13) | 0.348 |
| AG | 18 | 45.0 | 20.26 (14.97; 25.55) | 37 | 40.2 | 26.96 (23.77; 30.17) | 0.022 | |
| GG | 18 | 45.0 | 21.34 (15.41; 27.28) | 39 | 42.4 | 26.04 (22,68; 29.40) | 0.136 | |
| Newborns (n = 38) | ||||||||
| TaqI/A > G | AA | 18 | 47.4 | 27.95 (21.13 34.78) | 39 | 42.4 | 30.436 (27.510; 33.76 | 0.451 |
| AG | 16 | 42.1 | 27.64 (20.14; 35.15) | 46 | 50.0 | 32.76 (28.93; 36.59) | 0.186 | |
| GG | 4 | 10.5 | 21.58 (5.42; 37.74) | 7 | 7.6 | 31.60 (20.60; 42.59) | 0.192 | |
| BsmI/C > T | CC | 14 | 36.8 | 28.68 (20.09; 37.27) | 38 | 41.3 | 31.78 (27.85;35.72) | 0.441 |
| CT | 1 | 2.6 | 39.62 | 37 | 40.2 | 33.37 (42) | *** | |
| TT | 23 | 60.6 | 25.68 (20.21; 31.15) | 17 | 18.5 | 27.80 (22.87; 32.73) | 0.566 | |
| ApaI/C > A | CC | 6 | 15.7 | 26.78 (15.15; 38.40) | 23 | 25.0 | 33.31 (26.88; 39.74) | 0.326 |
| CA | 15 | 39.5 | 32.04 (23.34; 40.75) | 55 | 59.8 | 31.74 (28.70; 34.79) | 0.934 | |
| AA | 17 | 44.8 | 22.97 (17.37; 28.57) | 14 | 15.2 | 28.79 (24.99; 32.60) | 0.090 | |
| FokI/A > G | AA | 1 | 2.6 | 37.66 | 12 | 13.0 | 34.17 (25.64; 42.70) | *** |
| AG | 19 | 50.0 | 30.00 (23.72; 36.27) | 47 | 51.1 | 30.76 (27.75; 33.77) | 0.801 | |
| GG | 18 | 47.4 | 23.57 (18.87; 30.26) | 33 | 35.9 | 32.10 (27.44; 36.76) | 0.032 | |
N: Sample number. * Mean concentrations of 25(OH) D (confidence interval). **T-test. *** Not possible calculated due sample size. P < 0.05