Table 5.
The risks of prematurity in relation to the genotypes of the VDR variants, and their association with 25(OH) D deficiency in the mothers
| VDR SNVs | Genotypes | Odds | Prematurity Risk | |||
|---|---|---|---|---|---|---|
| All mothers (n = 132) | Mothers with 25(OH) D deficiency (n = 47) | |||||
| OR (CI 95%) | p* | OR (IC 95%) | p** | |||
| TaqI/A > G | AA | 0.76 | Ref. | Ref. | ||
| AG | 0.39 | 0.51 (0.23; 1.16) | 0.107 | 0.56 (0.25; 1.27) | 0.165 | |
| GG | 0.14 | 0.19 (0.05; 0.72) | 0.015 | 0.19 (0.05; 0.74) | 0.016 | |
| BsmI/C > T | CC | 0.44 | Ref. | Ref. | ||
| CT | 0.00 | *** | *** | *** | *** | |
| TT | 1.08 | 2.46 (1.07; 5.65) | 0.033 | 2.36 (1.02 5.47) | 0.044 | |
| ApaI/C > A | CC | 0.16 | Ref. | Ref. | ||
| CA | 0.43 | 2.66 (0.91; 7.78) | 0.075 | 3.00 (1.003; 8.99) | 0.050 | |
| AA | 1.17 | 7.23 (2.14; 24.48) | 0.001 | 7.99 (2.29; 27.84) | 0.001 | |
| FokI/A > G | AA | 0.25 | Ref. | Ref. | ||
| AG | 0.49 | 1.95 (0.57; 6.67) | 0.290 | 2.01 (0.58; 7.02) | 0.271 | |
| GG | 0.30 | 1.85 (0.54; 6.31) | 0.329 | 1.82 (0.53; 6.33) | 0.344 | |
SNV Single Nucleotide Variant, OR Odds Ratio, CI Confidence interval. Wild genotype was used as a reference for *Logistic regression
** Logistic regression adjusted for maternal vitamin D deficiency (≤30 ng/ml). *** Not possible to calculate due to sample size. P < 0.05