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. 2019 Dec 31;12:2. doi: 10.1186/s13148-019-0797-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Association between circulating nucleosome levels, anthropometric measures and body mass index (BMI) categories. Circulating nucleosomes are assayed by ELISA in Kardiovize participants (n = 120) and expressed as absorbance. a Correlation matrix between circulating nucleosome levels and anthropometric measures. The data are reported as the Spearman’s correlation coefficient and those with a p value < 0.05 are indicated in bold. b, c Comparison of circulating nucleosome levels between BMI categories. The data represent the median and interquartile range and are compared using the Mann-Whitney U or Kruskal–Wallis tests; ***p < 0.001. (D) ROC curve showing the ability of serum circulating nucleosomes to discriminate patients with severe obesity. BMI body mass index, WHR waist to hip ratio