Table 1.
Summary of gene level differential expression analysis in RPE samples in two different conditions (Prpf31A216P/+ vs WT mice). Default filter criteria, fold change < − 2 or > 2 and ANOVA p-value < 0.05
| Type of genes | Number of genes evaluated (%) | Number of genes differentially expressed (%) | Number of genes up-regulated (%) | Number of genes down-regulated (%) |
|---|---|---|---|---|
| Non-coding | 36,703 (55.7) | 562 (0.9) | 485 (47.0) | 77 (7.5) |
| Complex | 15,644 (23.7) | 280 (0.4) | 264 (25.6) | 16 (1.5) |
| Coding | 10,692 (16.2) | 151 (0.2) | 134 (12.9) | 17 (1.6) |
| Pseudogene | 2711 (4.1) | 40 (0.1) | 39 (3.8) | 1 (0.1) |
| Ribosomal | 155 (0.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Unassigned | 51(0.1) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Total | 65,956 (100.0) | 1033 (1.6) | 922 (89.3) | 111 (10.7) |
MTA 1.0, genome version mm10