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. 2019 Dec 31;20:1. doi: 10.1186/s12885-019-6169-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — BM-1197 induces apoptosis in a mitochondrial pathway. a. Caspase 3 activity in OCI-ly8 cells were measured 24 h after adding BM-1197 and were plotted relative to the DMSO control. b. Caspase 3 activity in OCI-ly8 cells were measured in indicated time points after adding BM-1197 and ere plotted relative to the DMSO control. c. Caspase 9 activity in OCI-ly8 cells was measured 24 h after treated with BM-1197 and was plotted relative to the DMSO control. d. Caspase 9 activity in OCI-ly8 cells was measured in indicated time points after adding BM-1197 and was plotted relative to the DMSO control. e. Cytochrome c (Cyt. c) expression in OCI-LY8 mitochondrial and cytosolic fractions were determined by western blot in indicated time points after adding BM-1197. COX IV and GAPDH serve as protein loading controls for the mitochondria and cytosol, respectively. f. Quantification of Cytochrome c (Cyt. c) abundance in OCI-LY8 mitochondrial and cytosolic fractions