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. 2019 Dec 22;25:9836–9843. doi: 10.12659/MSM.918405

Figure 1.

Figure 1

ATV ameliorates ox-LDL-induced apoptosis and migration of HUVECs. (A) CCK-8 assay was applied to analyze the inhibitory effects of ox-LDL (10, 20, 50, 100, and 200 mg/L) pre-treatment for 24 hours on HUVECs; n=6. ** P<0.01, *** P<0.001 compared to the CTL group. (B) The cell viability of HUVECs treated by various concentrations of ATV for 24 hours; n=6. ### P<0.001 compared to the CTL group. ** P<0.01, *** P<0.001 compared to the ox-LDL group. (C) TUNEL staining was applied to detect the apoptosis of HUVECs treated by 10 μM ATV for 24 hours. (D) Western blot was used to detect the expression of cleaved caspase-3 of HUVECs treated by 10 μM ATV for 24 hours. (E) Relative migration ratio, the mRNA levels of (F) MCP-1 and (G) ICAM-1 of HUVECs after being treated with 10 μM ATV and 100 mg/L ox-LDL for 24 hours. ### P<0.001 compared to the CTL group. ** P<0.01, *** P<0.001 compared to the ox-LDL group. ATV – atorvastatin; ox-LDL – oxidized low-density lipoprotein; HUVECs – human umbilical vascular endothelial cells; CCK-8 – Cell Counting Kit-8; CTL, control.