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. 2019 Dec 22;25:9836–9843. doi: 10.12659/MSM.918405

Figure 3.

Figure 3

ATV inhibits ox-LDL-induced apoptosis and migration of HUVECs by downregulating the expression of miR-26a-5p. (A, B) qRT-PCR was applied to detect the expression of miR-26a-5p in HUVECs after transfection with (A) miR-26a-5p mimic, (B) miR-26a-5p inhibitor and negative control (NC). (C) TUNEL staining was used to observe the percentage of apoptotic cells. (D–F) After being treated by ATV and ox-LDL for 24 hours, HUVECs were transfected with miR-26a-5p mimic, miR-26a-5p inhibitor, or NC to detect the (D) relative migration ratio, mRNA levels of (E) MCP-1 and (F) ICAM-1. Scale bar: 20 μm. ### P<0.001 compared to the CTL group. *** P<0.001 compared to indicated group. ATV – atorvastatin; ox-LDL – oxidized low-density lipoprotein; HUVECs – human umbilical vascular endothelial cells; qRT-PCR – quantitative real-time polymerase chain reaction; CTL – control.