Table 1.
Known substrates regulated by protein phosphatase activity of PTEN
| Putative target (site) | Cell type | Biological function | References |
|---|---|---|---|
| PTEN (S366) | U-87MG | Inhibits cell invasion, changes cell morphology | Tibarewal et al. 2012 |
| Dvl (S143) | hTERT RPE-1 | Stabilizes primary cilia | Shnitsar et al. 2015 |
| Rab7 (S72, Y183) | HeLa | Promotes recruitment of Rab7 to late endosomes and late endosome maturation | Shinde and Maddika (2016) |
| PTK6 (Y342) | PC3 | Inhibits progression of prostate adenocarcinoma | Wozniak et al. 2017 |
| IRS1 (Y612, Y989) | MEF (mouse embryonic fibroblast) | Inhibits IGF and insulin signaling | Shi et al. 2014 |
| FAK (Y397)a | U-87MG, NIH/3T3 | Inhibits cell spreading and migration | Tamura et al. 1998; Cai et al. 2005 |
| CREB (S133) | MEF, PE2 | Regulates CREB transcriptional activity and cell survival | Gu et al. 2011 |
| MCM2 (S41) | HCT116 | Regulates replication fork progression | Feng et al. 2015 |
| PLK1 (T210) | MEF | Regulates cell mitosis and polyploid formation | Zhang et al. 2016 |
IGF, Insulin-like growth factor.
aMultiple studies suggested dephosphorylation of this site is associated with PTEN but has not yet been verified as a direct substrate of PTEN.