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. 2020 Jan 1;34(1-2):72–86. doi: 10.1101/gad.331546.119

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© 2020 Koo et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — AP-1 induction is required for YAP-mediated organ size control. (A) Gross appearance of wild-type and hepatocyte-specific tetracycline-inducible YAP transgenic (YAP^HepTg) mice. All mice were given doxycycline in drinking water and treated with T-5224 (150 mg/kg) or vehicle for 17 d, starting at 3 wk of age. (B) Quantification of liver weight and liver/body weight ratio. (**) P < 0.01, compared with wild-type control; (##) P < 0.01, compared with YAP^HepTg control, by Student's t-test. (C) Representative H&E staining of liver sections. Scale bar, 50 µm. (D) Serum biochemical parameters show that hepatocytes are without significant damage.