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. 2020 Jan 1;34(1-2):87–98. doi: 10.1101/gad.331868.119

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© 2020 Shyian et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Replisome “sTOP” model (“slowing down with topoisomerases I–II”) Tof1–Csm3 promotes replication fork pausing at proteinaceous barriers (a) via topoisomerase I and II, either by recruiting topoisomerases to the replisome (b,c) to dampen positive torsion in front of the fork (d), or/and by recognizing topoisomerases bound at barriers (e) and potentially regulating CMG helicase activity (f) (Cho et al. 2013). (g) Tof1–Csm3 also suppresses fork rotation (Schalbetter et al. 2015). (h) sTOP function of Tof1–Csm3 is distinct from its Mrc1-shared role in DRC (DNA replication checkpoint). See the text for further details.