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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: Annu Rev Pathol. 2019 Jan 24;14:293–318. doi: 10.1146/annurev-pathmechdis-012418-012927

Figure 4.

Figure 4.

Tubulinopathies affect multiple processes in cortical development, and cause heterogeneous MCDs. Boxes represent the expression, functions, and MCDs associated with TUBA1A, TUBA8, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB5, and TUBG1. Abbreviations: CFEOM3: congenital fibrosis of extraocular muscles type 3; CP: cortical plate; H-ABC: hypomyelination with atrophy of the basal ganglia and cerebellum; IZ: intermediate zone; LIS: lissencephaly; LIS-CH: lissencephaly with cerebellar hypoplasia; MIC: congenital microcephaly; MLIS: microlissencephaly; MTOCs: microtubule organizing centers; MZ: marginal zone (Cajal-Retzius neurons in yellow); PAC: pachygyria; PMG: polymicrogyria; PMG-ONH: polymicrogyria with optic nerve hypoplasia; SBH: subcortical band heterotopia; SGP: simplified gyral pattern; SVZ: subventricular zone; VZ: ventricular zone.