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. 2019 Dec;16(12):855–871. doi: 10.11909/j.issn.1671-5411.2019.12.003

Figure 5. Expression of mitochondrial dynamics proteins is regulated in pulmonary vascular remodeling by HIF-1α.

Figure 5.

(A): The expression of mitochondrial fission and fusion mRNA in lung tissue were measured by the qRT-PCR; (B): the expression of mitochondrial fission and fusion mRNA in PASMCs were measured by the qRT-PCR; (C): the expression of mitochondrial fission and fusion protein in lung tissue were measured by the Western Blot analysis; (D): the expression of mitochondrial fission and fusion protein in PASMCs were measured by the Western Blot analysis; (E): the changes of mitochondrial fission and fusion protein in lung tissue were significantly different from the normoxia group; and (F): the changes of mitochondrial fission and fusion protein in PASMCs were significantly different from the normoxia group. Drp1: dynamin-related protein 1; Fis1: fission 1; HIF-1α: hypoxia-inducible factor-1α; Mfn1: mitofusin 1; Mfn2: mitofusin 2; OPA1: optic atrophy 1; PASMCs: pulmonary arterial smooth muscle cells; qRT-PCR: quantitative real-time polymerase chain reaction; siHIF-1α: small interfering hypoxia-inducible factor-1α.