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. 2019 Dec;16(12):855–871. doi: 10.11909/j.issn.1671-5411.2019.12.003

Figure 7. The mitochondrial dynamics is involved in the hypoxia-induced promotion of pulmonary vascular remodeling via Drp1.

Figure 7.

(A–B): Right heart catheterization analysis of mPAP and RVSP on the surviving rats; (C): the degree of right ventricular hypertrophy expressed as RV/(LV + S); (D): the measurement of medial wall thickness of distal pulmonary vessels; (E–F): representative images of TUNEL staining for the different experimental groups. Nuclei with red staining indicate TUNEL-positive cells (magnification, 400 ×); (G): immunohistochemical evaluation of the expression of PCNA in lung tissue (magnification, 200 ×); (H): immunohistochemical evaluation of the expression of Caspase 3 in lung tissue (magnification, 200 ×); and (I): Caspase 3 expression was decreased in pulmonary vessels with hypoxia, and PCNA expression was increased in pulmonary vessels with hypoxia. Drp1: dynamin-related protein 1; LV: left ventricle; mPAP: mean pulmonary arterial pressure; PCNA: proliferating cell nuclear antigen; RV: right ventricle; RVSP: right ventricular systolic pressure; S: septum.