Table 2. Adjusted OR (95% CI) of HRD and PRD by history of depression status for participants from the CLSA Comprehensive Cohort at baseline.

	Model 1 (n = 29,061)			Model 2 (n = 25,197)			Model 3 (n = 22,774)
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
HRD
Group 1	1.00			1.00			1.00
Group 2	1.39	1.23–1.58	< 0.0001	1.21	1.05–1.39	0.01	1.12	0.95–1.31	NS
Group 3	1.55	1.37–1.76	< 0.0001	1.44	1.25–1.64	< 0.0001	1.36	1.18–1.58	< 0.0001
Group 4	2.01	1.71–2.36	< 0.0001	1.53	1.28–1.83	< 0.0001	1.31	1.08–1.61	< 0.01
PRD
Group 1	1.00			1.00			1.00
Group 2	1.30	1.19–1.41	< 0.0001	1.15	1.04–1.27	< 0.005	1.07	0.96–1.18	NS
Group 3	1.46	1.34–1.58	< 0.0001	1.29	1.18–1.41	< 0.0001	1.20	1.09–1.32	< 0.0005
Group 4	1.88	1.69–2.09	< 0.0001	1.36	1.20–1.54	< 0.0001	1.17	1.02–1.34	< 0.03

CI: confidence interval; CLSA: Canadian Longitudinal Study on Aging; HRD: heart related disorders; NS: non-statistical significance; OR: odds ratio; PRD: peripheral/vascular related disorders. Group 1: CES-D10 score < 10 and negative clinical depression history; Group 2: CES-D10 score ≥ 10 and negative clinical depression history; Group 3: CES-D10 score < 10 and positive clinical depression history; Group 4: CES-D10 score ≥ 10 and positive clinical depression history. Model 1: adjusted for age, sex, and ethnicity; Model 2: further adjusted for body mass index, marital status, education, income, immigrant status, number of close friends, and life style factors (alcohol, smoking, and physical activity); Model 3: further adjusted for comorbidities.