Table 1.
Baseline characteristics
| Characteristics | GNRI > 98 (n = 133) | GNRI 92–98 (n = 95) | GNRI < 92 (n = 124) | P‐value |
|---|---|---|---|---|
| Age | ||||
| <65 years | 65 (48.9) | 46 (48.4) | 49 (39.5) | 0.136 |
| ≥65 years | 68 (51.1) | 49 (51.6) | 75 (60.5) | |
| Median, years (range) | 65 (36–80) | 65 (47–81) | 66 (48–81) | 0.066 |
| Sex | ||||
| Male | 123 (92.5) | 84 (88.4) | 111 (89.5) | 0.414 |
| Female | 10 (7.5) | 11 (11.6) | 13 (10.5) | |
| ECOG PS | ||||
| 0–1 | 122 (91.7) | 86 (90.5) | 93 (75.0) | < 0.001 |
| 2 | 11 (8.3) | 9 (9.5) | 31 (25.0) | |
| Brain metastasis | ||||
| Absent | 58 (43.6) | 39 (41.1) | 46 (37.1) | 0.143 |
| Present | 34 (25.6) | 32 (33.7) | 28 (22.6) | |
| Not evaluated | 41 (30.8) | 24 (25.3) | 50 (40.3) | |
| Regimen | ||||
| IP | 63 (47.4) | 47 (49.5) | 60 (48.4) | 0.867 |
| EP | 70 (52.6) | 48 (50.5) | 64 (51.6) | |
| Anemia | ||||
| Absent | 93 (69.9) | 54 (56.8) | 35 (28.2) | < 0.001 |
| Present | 40 (30.1) | 41 (43.2) | 89 (71.8) | |
| Thrombocytopenia | ||||
| Absent | 128 (96.2) | 87 (91.6) | 118 (95.2) | 0.682 |
| Present | 5 (3.8) | 8 (8.4) | 6 (4.8) | |
| Hyponatremia | ||||
| Absent | 105 (79.0) | 77 (81.1) | 81 (65.3) | 0.013 |
| Present | 28 (21.1) | 18 (19.0) | 43 (34.7) | |
| Median BMI (range), kg/m2 | 23.9 (17.9–34.8) | 22.8 (15.0–28.3) | 20.9 (14.8–27.8) | < 0.001 |
| Median PNI (range) | 54.7 (41.8–71.3) | 47.9 (37.7–60) | 41.4 (26.8–56.5) | < 0.001 |
BMI, body mass index; ECOG PS, Eastern Cooperative Oncology Group performance status; EP, etoposide/cisplatin; GNRI, Geriatric Nutritional Risk Index; IP, irinotecan/cisplatin; PNI, Prognostic Nutritional Index.