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. 2019 Dec 27;13(2):355–364. doi: 10.1016/j.tranon.2019.12.003

Figure 1.

Figure 1

ADIRcells are sensitive to nutrient stress and RTK inhibitor foretinib. (A) Phase-contrast morphology of five ADIR cells (58R1 to 58R5) and ADI-sensitive cells (A2058) cultured in medium containing charcoal-stripped FBS for 96 hours; (B) and (C) proliferation measurements of cells cultured under charcoal-stripped FBS for 96 hours by DNA fragmentation and by SRB assays, respectively; (D) and (E) cell proliferation measurements of A2058 and ADIR cells treated with foretinib (2 nM, 48 hours) and determined by SRB assay and by DNA fragment assay, respectively. RTK, receptor tyrosine kinase; SRB, sulforhodamine B.