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. 2019 Dec 27;13(2):355–364. doi: 10.1016/j.tranon.2019.12.003

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Interactions between Axl and EphA2 in response to ADI. (A) Inhibition of Axl activates RSK1 and EphA2 using dominant-negative (DN) Axl and soluble-Axl (s-Axl) recombinants in A2058 cells treated with ADI; (B) time-course suppression of TK-Mer and Tyro3 expression by ADI; (C) knockdown of Axl in two ADI^R (58R3 and 58R4) cells induces p-RSK1 and p-EphA2(S897) but downregulates TK-Mer and Tyro3, si-scr refers to scramble siRNA; (D) marginal regulation of Axl and RSK1 by EphA2 siRNA in A2058 cells; (E) Western blot assays showing that knockdown of EphA2 in two ADI^R cells moderately increase Axl expression.