Fig. 2.

The pathological images of the hippocampal CA1 zone of the Sham operated Group(A), the Model Group(B) and the MDP Group(C) at 200 times magnification. Three rats' hippocampus of each group were observed with Optical microscope. The obvious neuronal loss (B) and neuronal proliferation(C) can be seen. Moreover, the white matters are sparse in Model Group (B) and condense in MDP Group(C). Chart D shows that the HE staining images were analyzed with Image J software and the pyramidal cells were calculated, the results have significant difference (P < 0.05 or P < 0.01). there are 76 ± 14, 54 ± 18 and 102 ± 24 pyramidal neurons respectively in Sham operated Group, Model Group and MDP Group.