Table 1.
Monkey and scAAV2-Mediated Expression | Eye | Grade of Corneal Edema |
||
---|---|---|---|---|
Day 3 | Day 7 | Day 63 | ||
352 | ||||
EGFP | OS | 0 | 0 | 0 |
C3 | OD | 0 | 2 | 4 |
346 | ||||
EGFP | OS | 0 | 0 | 0 |
C3 | OD | 0 | 2 | 3 |
285 | ||||
EGFP | OS | 0 | 0 | 0 |
C3 | OD | 0 | 1 | 2 |
309 | ||||
EGFP | OS | 0 | 0 | 0 |
C3 | OD | 0 | 1 | 2 |
368 | ||||
EGFP | OS | 0 | 0 | 0 |
C3 | OD | 0 | 0 | 1 |
Monkeys were administered a dose of 3 × 1010 vgs. There were no other signs, including hyperemia, conjunctivitis, and flare. OS, left eye; OD, right eye.