Table 3.
Cross-sectional lipid associations with dysglycemia in FHS.
| Lipid Species | Lipid Class | Estimated β* | SE | P-value† | Replication# |
|---|---|---|---|---|---|
| Cer (d18:0/24:0) | Cer | 0.280 | 0.070 | 6.59E-05 | |
| LPC 18:1e | LPC | −0.279 | 0.073 | 1.50E-04 | ✓ |
| LPC 17:0 | LPC | −0.271 | 0.073 | 1.98E-04 | ✓ |
| SM 36:0 | SM | 0.275 | 0.075 | 2.43E-04 | |
| LPC 18:0e | LPC | −0.260 | 0.071 | 2.80E-04 | ✓ |
| LPC 16:1e | LPC | −0.254 | 0.072 | 4.48E-04 | ✓ |
| SM (d18:0/24:0) | SM | 0.265 | 0.075 | 4.79E-04 | |
| LPC 18:0p | LPC | −0.244 | 0.070 | 5.48E-04 | ✓ |
⁎
Estimated β coefficients represent the mean differences in standardized lipid measures between participants with and without dysglycemia.
†
The p-value threshold for significance in FHS (p < 5.7 × 10−4) was determined by the Bonferroni method [0.05/(22×4)].
#
The p-value threshold for replication in the ERF study, PESA cohort, and SAFHS of the lipid cross-sectional associations with dysglycemia was calculated using Bonferroni correction to be 8.33 × 10−3 (0.05/6).
✓ denotes lipid species that replicated in the ERF, SAFHS, or PESA.
Abbreviations: Cer = ceramide; LPC = lysophosphatidylcholine; SM = sphingomyelin.