Table 4.
Single marker associations with longitudinal changes in metabolic risk factors.
| Change in metabolic trait | Lipid species | Lipid class | Estimated β* | SE | P-value† | FDR | Partial R2 |
|---|---|---|---|---|---|---|---|
| BMI | LPC 16:0 | LPC | −0.57 | 0.14 | 6.7E-05 | 0.01 | 0.029 |
| LPC 18:0 | LPC | −0.50 | 0.13 | 1.7E-04 | 0.01 | 0.026 | |
| LPC 16:0e | LPC | −0.44 | 0.12 | 4.2E-04 | 0.02 | 0.023 | |
| LPC 22:5 | LPC | −0.45 | 0.13 | 4.3E-04 | 0.02 | 0.023 | |
| Glucose | SM 36:0 | SM | 3.71 | 0.91 | 5.0E-05 | 0.01 | 0.030 |
| LPC 18:1 | LPC | −3.37 | 0.93 | 2.9E-04 | 0.02 | 0.024 | |
| SM (d18:0/24:0) | SM | 3.34 | 0.92 | 3.2E-04 | 0.02 | 0.024 | |
| PC 36:2 | PC | −2.97 | 0.85 | 5.2E-04 | 0.02 | 0.022 | |
| HDL-C | SM (d18:2/24:1) | SM | 2.61 | 0.55 | 2.8E-06 | 0.00 | 0.040 |
⁎
Estimated β coefficients represent the mean differences in longitudinal change (native units) in the stated metabolic trait per one standard deviation difference in lipid measures.
†
The p-value threshold for significance (p < 5.7 × 10−4) was determined by the Bonferroni method [0.05/(22×4)].
Abbreviations: LPC = lysophosphatidylcholine; PC = phosphatidylcholine; SM = sphingomyelin.
Lipids also associated in cross-sectional analysis with the corresponding metabolic risk factor are shown in bold.