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. 2019 Nov 20;4(8):924–937. doi: 10.1016/j.jacbts.2019.07.008

Figure 1.

Figure 1

The Development of Cardiomegaly in the Lean Diabetic SKO Mice

Mice were subjected to phenotypic characterizations according to the protocol (A) and nuclear magnetic resonance (NMR) (B) to measure body weight and lean mass. (C) Blood glucose and serum insulin of mice (18 to 24 weeks old) under basal feeding; (D) the ratio between tissue weight and body weight of mice (∼24 weeks old); and (E) the ratio of left ventricular (LV), left atrial (LA), right ventricular (RV), and right atrial (RA) weight to body weight of mice (41 to 46 weeks old) were analyzed. *p < 0.05, compared with control (Ctrl) mice (n = 6). PV = pressure-volume; SKO = seipin knockout.