Figure 3.

Effect of Interleukin 5 Deficiency on Plasma Lipids and Low-Density Lipoprotein–Associated Autoantibodies

Effect of interleukin 5 (IL-5) deficiency on plasma lipids and low-density lipoprotein (LDL)–associated autoantibodies in Apoe^-/- mice (A,B).Apoe^-/- and IL5^-/-/Apoe^-/- mice had similar levels of cholesterol and triglycerides. (C to E) IL-5 is known to stimulate in the expression of the natural immunoglobulin M (IgM) antibodies. In accordance, IL-5–deficient mice had lower levels of IgM against copper oxidized LDL, whereas there were no differences in IgM against phosphoryl choline and malondialdehyde. Graphs are plotted as median with interquartile range. The p values were calculated using the Mann-Whitney U test. BSA = bovine serum albumin; PC = phosphoryl choline; RLU = relative luminescence intensities.