Figure 4.

Effect of Interleukin 5 Deficiency on Immunoglobulin M Accumulation and Apoptosis

Effect of interleukin 5 (IL-5) deficiency on immunoglobulin M (IgM) accumulation and apoptosis in plaques of Apoe^−/− mice IL-5 deficiency did not affect (A) the IgM content or (B) amount of terminal deoxynucleotidyl transferase deoxyuridine triphosphatase nick end labeling (TUNEL)–positive cells in plaques from low shear stress sites or in the oscillatory flow sites. Representative images of the IgM stain and TUNEL stain are shown under the respective graphs. IgM is shown in brown and TUNEL positive cells are shown with black arrows. Graphs are plotted as median with interquartile range. p values were calculated using the Mann-Whitney U test.