Table 1.
Baseline Clinical Characteristics and Interleukin 5 Levels in Subjects With or Without a Major Adverse Cardiac Event or Stroke During Follow-Up
| MACE |
Stroke |
|||||||
|---|---|---|---|---|---|---|---|---|
| No (n = 553) | Yes (n = 143) | HR (95% CI) | p Value | No (n = 574) | Yes (n = 122) | HR (95% CI) | p Value | |
| Age, yrs | 65.6 ± 1.1 | 65.7 ± 1.2 | 1.13 (0.97-1.31) | ns | 65.6 ± 1.1 | 65.6 ± 1.2 | 1.00 (0.85-1.18) | ns |
| Males, % | 36.7 | 52.4 | 1.78 (1.29-2.45) | <0.001 | 40.1 | 48.4 | 1.54 (1.08-2.20) | ns |
| Current smokers, % | 17.4 | 20.1 | 1.46 (0.97-2.21) | ns | 17.8 | 18.6 | 1.54 (0.97-2.46) | ns |
| Diabetes, % | 11.5 | 23.7 | 2.35 (1.59-3.47) | <0.001 | 13.3 | 17.2 | 1.53 (0.94-2.48) | ns |
| BMI, kg/m2 | 26.3 ± 4.0 | 26.7 ± 3.9 | 1.03 (0.99-1.07) | ns | 26.3 ± 4.0 | 26.3 ± 3.8 | 1.00 (0.96-1.05) | ns |
| f-glucose, mmol/l | 5.3 ± 1.4 | 5.6 ± 2.0 | 1.13 (0.97-1.31) | <0.001 | 5.3 ± 1.4 | 5.6 ± 1.8 | 1.15 (1.04-1.28) | 0.009 |
| LDL, mmol/l | 4.4 ± 1.0 | 4.4 ± 1.0 | 0.99 (0.84-1.17) | ns | 4.5 ± 1.0 | 4.2 ± 1.1 | 0.80 (0.66-0.98) | 0.028 |
| HDL, mmol/l | 1.4 ± 0.4 | 1.3 ± 0.4 | 0.41 (0.24-0.69) | 0.001 | 1.4 ± 0.4 | 1.3 ± 0.4 | 0.67 (0.39-1.16) | ns |
| Triglycerides, mmol/l | 1.3 (0.9-1.8) | 1.3 (1.0-1.8) | 1.16 (0.95-1.41) | ns | 1.3 (0.9-1.8) | 1.3 (1.0-1.8) | 1.17 (0.95-1.45) | ns |
| Systolic BP, mm Hg | 150 ± 19 | 155 ± 20 | 1.02 (1.01-1.02) | <0.001 | 151 ± 20 | 152 ± 19 | 1.01 (1.00-1.02) | ns |
| hsCRP, mg/l | 1.6 (0.8-3.10) | 1.7 (0.7-1.1) | 1.04 (1.01-1.07) | 0.005 | 1.6 (0.8-3.6) | 1.5 (0.6-3.1) | 1.03 (1.00-1.07) | ns |
| Plasma IL-5, pg/ml | 0.73 (0.50-1.36) | 0.70 (0.47-1.14) | 1.00 (1.00-1.01) | ns | 0.75 (0.50-1.34) | 0.65 (0.47-1.26) | 1.00 (1.00-1.01) | ns |
| Leukocyte IL-5 release, pg/ml | 3.8 (0-58.1) | 4.6 (0-84.1) | 1.00 (1.00-1.00) | ns | 4.40 (0-59.0) | 3.1 (0-62.9) | 1.00 (1.00-1.00) | ns |
Values are mean ± SD or median (interquartile range). Statistical comparisons between cases and controls were done using univariable Cox proportional hazards regression models.
BMI = body mass index; BP = blood pressure; CI = confidence interval; HDL = high-density lipoprotein; HR = hazard ratio; hsCRP = high-sensitivity C-reactive protein; IL = interleukin; LDL = low-density lipoprotein; MACE = major adverse cardiac event.