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GIPR antagonism enhances GLP-1R activity. A) IPGTT in the mice pretreated with the GLP-1R agonists Ex4 (0.1 nmol/kg) at the end of the study. B) Body weight of the mice fed a high-fat diet starting at 12 weeks of age and treated for 3 weeks with the GIPR Ab. C) IPGTT (1.5 g/kg) conducted after 3 weeks of treatment. Values are mean ± SEM, *p < 0.05 vs IgG control. Statistical tests used: Student's t-test (A) (AUC), (B), and 2-way ANOVA with a Bonferroni post-hoc test (A and C).
