Fig. 1.

Trajectory of structural atrophy, Aβ accumulation over 3 timepoints and tau deposition at timepoint 4. Top row: Across the timepoints, structural MRI revealed progressive ventricular dilatation and subtle hippocampal atrophy with respect to baseline (blue voxels). Middle row: Peak regions of amyloid accumulation were distributed in posterior regions, such as the precuneus. Over the course of study, the spatial extent of amyloid increased to encompass temporal regions. Bottom row: At T4, [¹⁸F]-AV1451 scan showed a stereotypical pattern of AD tau distribution that involved the bilateral precuneus and temporoparietal cortices. Abbreviations: Aβ, amyloid β; AD, Alzheimer's disease; MRI, magnetic resonance imaging.