Fig. 5.

GDH and ALS recruitments by the scytonemin BGC. (a) Scytonemin BGC from ' Nostoc punctiforme ' is composed of regulatory genes (green), genes that participate in scytonemin biosynthesis (blue) and genes devoted to precursor supply (brown). Eight EFs of the scytonemin BGC were found to have their origin within the 42 conserved EFs, as shown by asterisks. (b) Detailed view (zoom-in) of Cyanobacteria GDH expansion branch close to ScyB. Unexpectedly, many of the known scytonemin producers are not found in this branch. (c) Zoom-in of the ScyA branch, showing ALS expansions correctly and exclusively marked by EvoMining with a fate in specialized metabolism. Known scytonemin producers are marked with stars. Squares indicate expansions devoted to specialized metabolism located in the genomic vicinity of GDH expansions that coincide with the ScyB branch. Cyanobacteria EvoMining trees of trpA, trpB, trpC, trpD, trpE and aroB are available in Microreact (Table S3).