Fig. 7.

Phylogenomic analysis of scyA and sycB showed chemical diversity around the scytonemin BGC. Genomic vicinities containing both scyA and scyB in Cyanobacteria are shown next to a phylogenetic reconstruction using the protein sequences of these two genes. EvoMining classification for the ALS family is shown in a circle. Relevant accessory genes in variants of scytonemin BGC, highlighted by coloured boxes that define phylogenetic clades with biosynthetic signals, are labelled as follows: hydrolases (blue pattern), prenyltransferases (yellow pattern), phosphodiesterases (purple pattern), monooxygenases (pink pattern), tyrosinases (grey pattern) and amidases (orange pattern). The NRPS and PKS from the basal branches are coloured in green and black patterns, respectively. Five putative chemical structures related to scytonemin were predicted considering biosynthetic logics and gain-and-losses of key genes, as shown in the hand-right panel of the figure.