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. 2019 Oct 28;39(1):e101828. doi: 10.15252/embj.2019101828

Figure 6. Robust gene co‐expression modules indicate that mTEC gene co‐expression has order.

Figure 6

  1. t‐SNE visualisation of the partition of 22,819 genes into 50 mutually exclusive gene modules. Each dot represents a gene and is coloured according to gene expression category (AIRE‐dependent, AIRE‐enhanced, AIRE‐independent TRG, Other, Housekeeping, Unclassified) as described in Fig 7A. The colour intensity of each dot/gene is proportional to its membership probability within each module.
  2. Histogram of adjusted mutual information (AMI) between random samples. The mean AMI value is indicated by a vertical purple line; AMI values lie between 0 and 1.
  3. Pearson correlation of co‐expression frequency for pairs of TRGs (AIRE‐regulated and AIRE‐independent) between individual mice or all mice pooled together (see Table EV1 for mouse identifiers). Mean correlation = 0.75, with the largest divergence observed between samples with higher read depth (B6_3‐B6_7, and F1_1_2).