Table:
Parkinson’s disease Clinical subtype | ||
---|---|---|
Clinical features | PDT | PDAR |
Progression of motor symptoms | Slower/not worsening | Faster |
Motor Fluctuations (on and off)/Freezing gait | Less | More |
Inheritance | Higher prevalence of Essential Tremor | Higher familial incidence of other cases of PD |
PET Scan | Does not correlate with nigrostriatal dopaminergic deficit | Correlates with nigrostriatal dopaminergic deficiency |
SPECT | ||
Pathology | Less neuronal loss in locus coeruleus, medial and lateral parts of SN | Higher neuronal losses in locus coeruleus, medial and lateral parts of SN |
DLPFC= dorsolateral prefrontal cortex; PET= positron emission topography; SPECT= single-photon emission computed tomography; PDT = tremor-dominant Parkinson’s patients; PDAR= akinetic and rigid-dominant Parkinson’s patients; SN= substantia nigra