Table 1.
KorAHF [36] | KorHF [37] | ASIAN-HF [38] | ATTEND [39] | ADHERE [40, 41] | ESC-HF-LT [42] | |
---|---|---|---|---|---|---|
2011–2014 | 2004–2009 | 2012–2015 | 2007–2011 | 2002–2004 | 2011–2013 | |
N | 5625 | 3200 | 5276 | 4837 | 159,168 | 4449 |
Age, years (SD) | 68.5 (14.5) | 67.6 (14.3) | 59.6 (13.1) | 73.0 (13.8) | 72.4 (14.1) | 69.4 (13.0) |
Male, % | 53.2 | 55.9 | 78.2 | 57.9 | 48.4 | 62.6 |
BMI, kg/m2 | 23.3 (3.9) | 23.2 (4.0) | 24.9 (5.1) | 28.7 (5.4) | ||
NYHA class III-IV, % | 84.8 | 74.0 | 35 | 81.4 | 76 | 85.2 |
SBP, mmHg | 131.2 (30.3) | 130.5 (3.2) | 118.4 (20.2) | 145.5 (36.7) | 143.9 (33.2) | 133.5 (28.2) |
DBP, mmHg | 78.6 (18.8) | 77.9 (18.0) | 72.4 (12.6) | 82.6 (22.6) | 77.7 (20.2) | |
HR, beats/minute | 92.6 (26.0) | 91.2 (25.4) | 79.7 (16.2) | 98.6 (29.1) | 90.8 (25.3) | |
EF, % | 37.7 ± 15.6 | 38.5 ± 15.7 | 28 [22, 33] |
53.4% with EF <40% |
37.8 ± 17.3 | 39.0 [30, 43] |
Etiology (%) | ||||||
- Hypertension | 4.0 | 36.7 | 18 |
Up to 30% in EF ≥ 55% |
8.2 | |
- Ischemic heart disease | 37.6 | 52.3 | 47.0 | 31.1 | 56.5 | |
Medical history (%) | ||||||
- Hypertension | 62.2 | 46.5 | 51.9 | 69.3 | 73.9 | 65.6 |
- Ischemic heart disease | 42.9 | 50.2 | 57.5 | 53.8 | ||
- Diabetes mellitus | 40.0 | 30.5 | 40.4 | 36.2 | 44 | 39.0 |
- Atrial fibrillation / atrial flutter | 28.5 | 20.8 | 17.9 | 39.6 | 30.9 | 44.0 |
- Renal insufficiency | 14.3 | 9.2 | 30.1 | 25.3 | ||
- Stroke / transient ischemic attack | 15.2 | 18.9 | 6.4 | 14.0 | 12.5 | |
- Chronic lung disease | 11.3 | 3.5 | 8.3 | 9.5 | 31.4 | 20.1 |
- Previous heart failure | 47.8 | 29.6 | 64.1 | 36.1 | 75.6 | 70.9 |
Medications at discharge | ||||||
- ACE inhibitor | 29.5 | 17.9 | 51.0 | 70–75 | 83.1 | 77.0 |
- Angiotensin receptor blocker | 39.7 | 39.4 | 26.9 | |||
- Beta blocker | 49.9 | 58.6 | 78.8 | 67 | 80.1 | 72.6 |
- Aldosterone antagonist | 44.9 | 53.1 | 59.4 | 40–50 | 32.8 | 53.9 |
- Diuretic | 68.1 | 81.5 | 87.2 | 83.9 |
SD standard deviation, BMI body mass index, NYHA New York heart association functional class, SBP systolic blood pressure, DBP diastolic blood pressure, EF ejection fraction, ACE angiotensin converting enzyme