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. 2020 Jan 2;18:3. doi: 10.1186/s12951-019-0566-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Improvement of anti-cancer activities of ceragenins CSA13, CSA-90 and CSA-192 after their immobilization on the surface of magnetic nanocarriers. a The level of lactate dehydrogenase release from lung carcinoma A549 and colon cancer DLD-1 cells after treatment with 10 µg/mL of ceragenin CSA-13 and its magnetic derivative. b IC50 values recorded for CSA-90, CSA-192 and their mixture with MNP against malignant melanoma A7, lung carcinoma A549, colon cancer DLD-1 and breast cancer MCF-7 cells. c Alterations in morphology and DNA fragmentation in colon cancer DLD-1 cells after their treatment with CSA-13 and MNP@CSA-13 at dose of 10 µg/mL for 24 h, investigated using phase contrast and fluorescence microscope, respectively