Table 3.
Key patents covering phage-displayed antibody libraries
| Patent | Title | Company | Date filed | Date granted | Date of expiry |
|---|---|---|---|---|---|
| US5223409 | Directed evolution of novel binding proteins | Dyax | 03/01/1991 | 06/29/1993 | 6/29/2010 |
| US5885793 | Production of anti-self antibodies from antibody segment repertoires and displayed on phage | Cambridge Antibody Technology (CAT, now Medimmune) | 12/02/1992 | 03/23/1999 | 3/23/2016 |
| US6582915 | Production of anti-self bodies from antibody segment repertories and displayed on phage | Cambridge Antibody Technology (CAT, now Medimmune) | 11/28/2000 | 06/24/2003 | 09/23/2012 |
| US5969108 | Methods for producing members of specific binding pairs | Cambridge Antibody Technology (CAT, now Medimmune) | 07/10/1991 | 10/19/1999 | 10/19/2016 |
| US6172197 | Methods for producing members of specific binding pairs | Cambridge Antibody Technology (CAT, now Medimmune) | 06/07/1995 | 01/09/2001 | 01/09/2018 |
| US5821047 | Monovalent phage display | Genentech | 6/5/1995 | 10/13/1998 | 10/13/2015 |
| US6706484 | Protein/(poly) peptide libraries (HuCAL libraries) | Morphosys AG | 01/24/2000 | 03/16/2004 | 08/19/2016 |
| US6753136 | Methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds (HuCAL GOLD libraries) | Morphosys AG | 03/15/2001 | 03/21/2002 | 02/06/2021 |