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. 2019 Dec 27;13:4375–4387. doi: 10.2147/DDDT.S224909

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© 2019 Yang et al.

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EPZ004777 attenuated oxidative stress and inhibited the PI3K/AKT pathway in rats.

Notes: (A) Western blotting analyses for the protein expression of PI3K in rats treated with or without EPZ004777 at 14 days of reperfusion time and quantification. (B) Western blotting analyses for the protein expression of p-AKT and AKT in rats treated with or without EPZ004777 at 14 days of reperfusion time and quantification. (C–E) SOD activity, MDA content, and H₂O₂ production were detected in rats subjected to I/R with or without EPZ004777. Values are expressed as the mean±SEM; *P<0.05 relative to the sham group, ^#P< 0.05 relative to the I/R+DMSO group.

Abbreviations: PI3K, phosphatidylinositol 3-kinase; AKT, serine-threonine protein kinase; p-AKT, phosphorylated-AKT; SOD, superoxide dismutase; MDA, malondialdehyde; H₂O₂, hydrogen peroxide; I/R, ischemia/reperfusion; DMSO, dimethyl sulfoxide; EPZ, EPZ004777; SEM, standard error of mean.