Table 2.
Multivariate-adjusted analysis of complications in patients with and without opioid use disorder.
| Complication | Nonopioid dependent | Opioid dependent | Odds ratioa | p value (multivariate) |
|---|---|---|---|---|
| Prosthetic joint infection | 22,702 (0.7%) | 190 (1.9%) | 1.55 (1.23–1.94) | <0.001 |
| Superficial surgical site infection | 24,020 (0.7%) | 216 (2.2%) | 1.66 (1.34–2.05) | <0.001 |
| Noninfectious wound complication | 30,492 (0.9%) | 209 (2.1%) | 1.40 (1.12–1.76) | 0.003 |
| Prosthetic complication | 36,874 (1.1%) | 217 (2.2%) | 1.37 (1.10–1.70) | 0.005 |
| Revision | 33,965 (1.0%) | 238 (2.4%) | 1.47 (1.19–1.81) | <0.001 |
| Postoperative pain | 135,788 (4.0%) | 1,405 (14.3%) | 2.97 (2.72–3.23) | <0.001 |
aOdds ratio with 95% confidence interval obtained through multivariate regression on matched cohorts while controlling for patient and operative characteristics.