Figure 6.

NEXMIF KO mice show impairments in Barnes maze spatial learning and memory. A, Quantification of the primary latency (in seconds) to find the target hole across all training trials (4 trials per day over 4 d) for WT and KO animals. B, Quantification of the types of search strategies used for locating the target hole over the 4 training days. C, Traces of track paths in the Barnes spatial memory maze during the 5 d memory probe for WT and KO animals. D, Distribution of nose pokes on the board showed no difference 24 h after training. E, Quantification of the distribution of nose pokes across different holes on the board showed a significant decrease for the target and adjacent holes in the 5 d memory probe. F, G, Primary latency to the target hole (F) and total track length (G) were increased in the KO animals probing both 1 and 5 d after training Data are represented as average ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001. ns, Not significant.