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. 2019 Dec 5;105(1):38–46. doi: 10.3324/haematol.2018.211334

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Figure 1. — Schematic model of the interplay between hematopoietic stem cells and the microenvironment during aging. Loss of β₃-adrenergic receptor (β₃-AR) activity reduces endosteal niches, pushes hematopoietic stem cells (HSC) away from the endosteum and favors myeloid bias at the expense of lymphopoiesis. Accumulation of aged HSC in the central bone marrow and increased β₂-AR activity causes expansion of central capillaries, myeloid cells and megakaryocytes, which locate farther from HSC.