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. 2019 Apr 11;105(1):83–90. doi: 10.3324/haematol.2018.211391

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Figure 5. — Relation between vasoconstriction during pain anticipation and perceived stress (state anxiety) in sickle cell disease subjects and controls. State anxiety was determined at baseline by the State-Trait Anxiety Inventory Y-1 questionnaire (STAI Y-1) and assessed in response to change in microvascular blood-flow during pain anticipation (PA) in sickle cell disease (SCD) subjects (closed circles, —) and controls (open diamonds, - - -). SCD subjects who were highly anxious at baseline had a smaller vasoconstriction response during the PA task than the SCD subjects who were less anxious (P=0.002); this effect was not seen among controls. MBF: microvascular blood flow.