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. 2019 Nov 23;4(1):50–65. doi: 10.1002/hep4.1440

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Secretome analysis of platelets with CD36 blockade. (A) Experimental flow diagram of secretome analysis using high‐resolution mass spectrometry. (B) Heat map representation of secretome for HMA+CD36:HMA; HNA+CD36:HNA1; and HNA2+CD36:HNA2 represents distinct secretome in HNA2 group comparison. Red Venn represents proteins that are induced/increased, and green Venn represents proteins that get reduced/inhibited with CD36 neutralization (P < 0.05). (C) Pathway overrepresentation analysis (Kyoto Encyclopedia of Genes and Genomes/Reactome) of HNA2‐specific 153 protein‐induced and 23 HNA2‐specific proteins inhibited under CD36 neutralization (P < 0.05, C‐score > 1).