Table 1.
Baseline Clinical Parameters of All Patients (Demographic Profile)
| Discovery Cohort | Validation Cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SAH (n = 10) | HC (n = 10) | SAH (n = 40) | AC (n = 20) | HC (n = 20) | P Value | P Value | P Value | P Value | |
| A | B | C | D | E | A vs. B | A vs. C | A vs. D | C vs. E | |
| Gender (male %) | 100 | 80 | 100 | 100 | 90 | — | — | — | — |
| Age (years) | 44 ± 8 | 32 ± 10 | 45 ± 8 | 46 ± 9 | 38 ± 9 | 0.21 | 0.71 | 0.62 | 0.68 |
| Height (cm) | 167.5 ± 4.1 | 170.1 ± 4.0 | 169.5 ± 7.1 | 171.5 ± 6.1 | 170.1 ± 4.0 | 0.85 | 1.41 | 0.55 | 0.51 |
| Weight (kg) | 70.6 ± 16.6 | 68.5 ± 12.8 | 72.2 ± 17.1 | 75 ± 16.5 | 71.1 ± 11.1 | 0.46 | 1.13 | 0.75 | 0.88 |
| BMI (kg/m2) | 24.5 ± 3.4 | 21.8 ± 2.7 | 25.5 ± 4.7 | 24.5 ± 5.6 | 22.3 ± 2.3 | 0.05 | 0.71 | 0.08 | <0.05 |
| Jaundice duration (days) | 24 ± 20 | — | 25 ± 21 | — | — | — | 0.71 | — | — |
| Baseline Laboratory Parameters of All Patients | |||||||||
| Total bilirubin (mg/dL) | 6.0 ± 3.0 | 0.6 ± 0.4 | 5.0 ± 4.0 | 2.3 ± 3.0 | 0.7 ± 0.3 | <0.001 | 0.71 | <0.001 | <0.01 |
| Direct bilirubin (mg/dL) | 1.64 ± 1.8 | 0.1 ± 0.1 | 1.74 ± 1.7 | — | 0.1 ± 0.1 | — | 0.07 | — | <0.01 |
| AST (IU/L) | 80.4 ± 47.6 | 20.0 ± 8.0 | 76.6 ± 49.2 | 34 ± 41.2 | 18.0 ± 10.0 | <0.001 | 2.67 | <0.001 | <0.01 |
| ALT (IU/L) | 42.0 ± 32.7 | 16.0 ± 5.1 | 42.0 ± 32.7 | 40 ± 31.5 | 16.0 ± 5.1 | <0.01 | 0.35 | <0.01 | <0.01 |
| Albumin (g/dL) | 2.7 ± 0.5 | 4.1 ± 1.0 | 2.9 ± 0.7 | 4.0 ± 0.9 | 4.1 ± 1.0 | <0.001 | 0.14 | <0.001 | <0.05 |
| PT (seconds) | 24.2 ± 8.1 | 11.6 ± 0.6 | 23.4 ± 9.1 | 18.1 ± 5.2 | 11.6 ± 0.6 | <0.001 | 0.57 | <0.001 | <0.01 |
| INR | 2.3 ± 0.6 | 0.9 ± 0.3 | 2.2 ± 0.7 | 1.1 ± 0.2 | 0.9 ± 0.3 | <0.001 | 0.07 | <0.001 | <0.01 |
| Hb (g/dL) | 9.2 ± 1.7 | 12.9 ± 0.5 | 9.4 ± 1.6 | 11 ± 1.5 | 12.9 ± 0.5 | <0.001 | 0.14 | <0.001 | <0.05 |
| TLC (cells/µL) | 6.3 ± 2.7 | 5.6 ± 1.7 | 6.1 ± 2.9 | 5.9 ± 1.6 | 5.6 ± 1.7 | <0.05 | 0.07 | <0.05 | <0.05 |
| Platelet count (cells/µL) | 65.5 ± 15.5 | 190.0 ± 20.0 | 63.4 ± 12.5 | 160 ± 31.5 | 190.0 ± 20.0 | <0.01 | 1.48 | <0.01 | <0.01 |
| Neutrophil % of TLC | 88.4 ± 44.6 | 55.0 ± 12.0 | 83.4 ± 40.4 | 60 ± 20 | 55.0 ± 12.0 | <0.01 | 3.54 | <0.01 | <0.01 |
| Baseline Severity Parameters of All Patients | |||||||||
| Child‐Turcotte‐Pugh score | 16 ± 4 | — | 18 ± 4 | 12 ± 4 | — | — | 1.41 | — | — |
| MELD score | 23 ± 8 | — | 25 ± 7 | 16 ± 4 | — | — | 1.57 | — | — |
| MELD plus sodium score | 75 ± 46 | — | 76 ± 56 | 22 ± 10 | — | — | 0.61 | — | — |
| Discriminant function score | 9 ± 3 | — | 10 ± 2 | 6 ± 2 | — | — | 0.78 | — | — |
| Age bilirubin INR creatinine score | 8.2 ± 2.3 | — | 7.8 ± 2.7 | 6 ± 1 | — | — | 0.55 | — | — |
For continuous variables, descriptive statistics are presented as mean ± SD, whereas for categorical variables, statistics are presented as number (percentage).
Abbreviations: AC, alcoholic cirrhosis; BMI, body mass index; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Hb, hemoglobin; INR, international normalized ratio; PT, prothrombin time; TLC, total leukocyte count.