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. 2019 Nov 12;4(1):92–108. doi: 10.1002/hep4.1448

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Hmgb1 ^ΔIEC mice display HFCFD‐induced atypical LD accumulation in the jejunum after 1 week. WT and Hmgb1 ^ΔIEC mice were fed the CD or HFCFD for 1 week. (A) H&E staining (top) and BODIPY FA staining (bottom) of the jejunum (yellow arrows: LD). (B) Pathology scores. (C) FITC‐Dextran concentration in portal serum indicative of gut permeability. (D) IEC TG, CHO, and NEFA and HMGB1 levels in portal serum. Data are expressed as mean ± SEM except for LD frequency, which is shown as the number of cases per group (n ≥ 8 mice/group). ^† P < 0.05, ^†† P < 0.01, and ^††† P < 0.001 for HFCFD versus CD; *P < 0.05 and **P < 0.01 for Hmgb1 ^ΔIEC versus WT mice.