FIG. 10.
Risk genes in African descent and Hispanic ethnicity. Depicted are the seven top risk single nucleotide polymorphisms/genes that are unique to ARDS risk in African descent individuals and to ARDS survival. The genes were identified via interrogation of GWAS results (HEATR1, SELPLG) or via candidate gene approaches and sequencing (S1PR3, MYLK, DIO2, GADD45a). DIO2, iodothyronine deiodinase 2; GADD45a, growth arrest and DNA damage-inducible gene; MYLK, myosin light chain kinase; S1Ps, sphingosine 1-phosphate receptors.