TABLE 1.
Characteristics of the study subjects analyzed for the interaction between the SNPs selected based on the GWA analysis and habitual PA, according to PA tertiles
| Characteristics | Men (n = 4,830) | Women (n = 5,540) | ||||||||
| Low PA (n = 1,581) | Medium PA (n = 1,642) | High PA (n = 1,607) | ρa | P | Low PA (n = 1,815) | Medium PA (n = 1,870) | High PA (n = 1,855) | ρa | P | |
| Age (years) | 54.1 (9.0) | 54.9 (9.5) | 55.0 (9.7) | 0.047 | 0.001 | 53.2 (9.5) | 53.9 (9.5) | 54.4 (9.0) | 0.049 | 0.0003 |
| Height (cm) | 168.2 (6.3) | 167.6 (6.2) | 166.6 (6.5) | −0.105 | <0.0001 | 155.1 (5.8) | 155.0 (5.7) | 154.3 (5.9) | −0.063 | <0.0001 |
| Weight (kg) | 67.9 (10.0) | 67.1 (10.5) | 65.8 (9.9) | −0.098 | <0.0001 | 54.2 (8.6) | 53.0 (7.6) | 53.6 (8.5) | −0.031 | 0.019 |
| BMI (kg/m2) | 24.0 (3.1) | 23.9 (3.3) | 23.7 (3.1) | −0.051 | 0.0004 | 22.6 (3.5) | 22.1 (3.2) | 22.5 (3.4) | 0.002 | 0.867 |
| Smoking status [n (%)] | −0.004 | 0.785 | 0.016 | 0.222 | ||||||
| Never | 417 (26.38) | 464 (28.3) | 439 (27.3) | — | — | 1556 (85.7) | 1635 (87.4) | 1561 (84.2) | — | — |
| Former | 596 (37.7) | 659 (40.1) | 597 (37.2) | — | — | 111 (6.1) | 115 (6.2) | 146 (7.9) | — | — |
| Current | ||||||||||
| 1‒19 (cigarettes/day) | 167 (10.56) | 155 (9.4) | 152 (9.5) | — | — | 90 (5.0) | 89 (4.8) | 102 (5.5) | — | — |
| 20+ (cigarettes/day) | 401 (25.36) | 364 (22.2) | 419 (26.1) | — | — | 58 (3.2) | 31 (1.7) | 46 (2.5) | — | — |
| Alcohol consumption [n (%)] | 0.060 | <0.0001 | 0.020 | 0.145 | ||||||
| Never | 356 (22.52) | 322 (19.6) | 305 (19.0) | — | — | 1164 (64.1) | 1153 (61.7) | 1144 (61.7) | — | — |
| Former | 48 (3.0) | 44 (2.7) | 41 (2.6) | — | — | 33 (1.8) | 31 (1.7) | 29 (1.6) | — | — |
| Current | ||||||||||
| 0.1‒22.9 (g/day) | 554 (35.0) | 617 (37.6) | 518 (32.2) | — | — | 526 (29.0) | 596 (31.9) | 592 (31.9) | — | — |
| 23.0‒45.9 (g/day) | 294 (18.6) | 323 (19.7) | 327 (20.4) | — | — | 63 (3.5) | 71 (3.8) | 63 (3.4) | — | — |
| 46.0+ (g/day) | 329 (20.81) | 336 (20.5) | 416 (25.9) | — | — | 29 (1.6) | 19 (1.0) | 27 (1.5) | — | — |
| PA (MET·h/day) | 3.16 (1.54) | 10.17 (2.58) | 30.92 (13.37) | 0.943 | <0.0001 | 3.51 (1.97) | 11.06 (2.72) | 28.61 (12.34) | 0.943 | <0.0001 |
| HDL-C (mg/dl)b | 54.0 (1.3) | 54.9 (1.3) | 57.4 (1.3) | 0.098 | <0.0001 | 64.9 (1.3) | 65.8 (1.3) | 65.9 (1.3) | 0.022 | 0.105 |
| Total cholesterol (mg/dl)c | 206.3 (32.8) | 205.2 (32.4) | 205.4 (33.3) | −0.011 | 0.473 | 216.2 (37.3) | 216.0 (35.2) | 215.8 (35.0) | −0.001 | 0.943 |
Values are mean (SD) for continuous variables and number (percentage) for categorical variables.
a
Spearman’s rank correlation coefficient.
b
Geometric mean (geometric SD).
c
Based on 4,429 males and 5,091 females.