Figure 2. Ciclopirox olamine (CPX) can suppress HSV-1-induced blepharitis.
Groups of 10 mice were infected on the corneas with 1×104 pfu HSV-1 KOS, and subsequently treated thrice daily for 5 d with saline, or with CPX or ACV at the indicated doses per eye. Blepharitis was assessed daily in masked fashion for 14 d post-infection. Data represent the mean ± SD of 40 mice and are the combined results of two experiments. *, P = 0.05–0.0183; **, P = 0.0065–0.0014; ***, P < 0.0005 for treatment group compared with saline control.