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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Antiviral Res. 2018 Jun 15;156:102–106. doi: 10.1016/j.antiviral.2018.06.010

Figure 4. Ciclopirox olamine (CPX) treatment suppresses HSV-1 strain 17 infection.

Figure 4.

Groups of 5 mice were infected on the scarified corneas with 1×104 pfu of HSV-1 strain 17, and subsequently treated thrice per day with saline or the indicated drug. A) Virus shed from the corneal epithelium over time post-infection. *, P = 0.0156; **, P = 0.004; ***, P = 0.0008 for ciclopirox compared with saline control by ANOVA. Acyclovir compared with saline control, P < 0.0001 for days 2–4. B) Quantity of viral genomes in the TG 4 d post-infection. *, P = 0.0408–.0396 for both treatment groups compared with saline control by ANOVA. Data represent the mean ± SEM of 10 mice (20 TG) and are the combined results of 2 experiments.