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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Microcirculation. 2016 Feb;23(2):134–145. doi: 10.1111/micc.12248

Figure 2-. NO bioavailabilty and eNOS activity under normoxia and hypoxia.

Figure 2-

NO generation in the vasculature under normoxic conditions occurs through activation of the eNOS enzyme involving L-arginine substrate conversion to L-citrulline plus NO. eNOS generation of NO under hypoxic conditions can become dysfunctional due to enzyme uncoupling and ROS formation. Alternative non-enzymatic generation of NO under hypoxia can occur through nitrite/nitrate reduction back to NO via different molecular pathways.